Onder 2.6. Gerechtshof Den Haag 7 november 2017

[0022] The composition of the invention, which combines a vitamin D analogue and a topical steroid, provides synergy in the form of additional benefit to the patient apart from the direct therapeutic value of the active substances. It has been shown that the skin irritative side effects of a vitamin D analogue, such as calcipotriol, is alleviated by the simultaneous application of a steroid, such as betamethasone, onto psoriatic skin, an effect that is only attainable using a two- component or multi- component treatment regimen where a vitamin D analogue and a steroid cannot be applied simultaneously to affected skin due to incompatibility of the praparations. When both a vitamin D analogue and a topical steroid are used in a combination treatment of psoriasis it has hitherto been necessary to use separate applications, typically one in the morning and the other in the evening, making it impossible to obtain any synergistic effect of the two types of active compounds (cf. Ortonne, J.P., Nouv. Dermatol., 1994, 13 (10), p. 746- 751), or where a certain degree of synergistic effect, such as less skin irritation, has been reported for a two- component regiment (cf. Kragballe, K. et al. Br J Dermatol 1998 Oct; 139 (4): 649- 54, and Ruzicka, T. et Lorenz, B. Br J Dermatol 1998, 138 (2), 254- 58) a substantial proportion of psoriasis patients will not benefit due to non- compliance with the treatment regimen.

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