Citaat | Gerechtshof Den Haag 7 november 2017
Onder 2.9. Gerechtshof Den Haag 7 november 2017
Een alinea uit Gerechtshof Den Haag 7 november 2017, ECLI:NL:GHDHA:2017:4029.
It is common general knowledge that combining corticosteroids and vitamin D analogues in a single formulation for treating psoriasis provides better patient compliance and results in less side effects (in D11 and in D60, page 132). Moreover, it is known that calcipotriol is instable in acidic media (D20a and D12). In D20a, it is further suggested to formulate the instable vitamin D analogue in a hydrophobic or anhydrous solvent selected from fatty acid esters, higher alcohols and propylene carbonate and a lipophilic base such as white petrolatum or a mixture of white petrolatum and liquid paraffin (claim 1 of 020a). The examples show stable non-aqueous ointments using isopropyl myristate as solvent.
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