Onder 2.24 Gerechtshof Den Haag 18 augustus 2020

Applicant is the first to demonstrate a Ca2+ receptor protein in parathyroid cells, and to pharmacologically differentiate such Ca2+ receptors in other cells, such as c-cells and osteoclasts. Applicant is also the first to describe methods by which molecules active at these Ca2+ receptors can be identified and used as lead molecules in the discovery, development, design, modification and/or construction of useful calcimimetics or calcilytics which are active at Ca2+ receptors. Such calcimimetics or calcilytics are useful in the treatment of various disease states characterized by abnormal levels of one or more components, (…) Identification of such lead molecules was impeded by the prior lack of a high-throughput screening system to discover active molecules, and the absence of a structural data base upon which to design effective drug candidates. These barriers are now removed by cloning the parathyroid cell Ca2+ receptors and functionally related receptors, and systematically examining the structural features of certain lead molecules that activate such cloned receptors and functionally related receptors. (…)

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