Citaat | Gerechtshof 's-Gravenhage 24 januari 2012

Alinea 207 Gerechtshof 's-Gravenhage 24 januari 2012

Een alinea uit Gerechtshof 's-Gravenhage 24 januari 2012, ECLI:NL:GHSGR:2012:BV1963.

dr. Bøgesø (89-101) te lezen: 'At this stage of the project, towards the end of 1987 and some 7 years after starting, we decided to look again at the diol route' (...)'At this point, we still needed to create a method to produce larger quantities of the enantiomers of citalopram. We therefore pursued the diol route further and sought to prepare diastereomeric salts of the diol with resolving agents. I proposed that Jens Perregaard attempt this resolution with di-p-toluoyltartaric acid. I do not recall if he tried other resolving agents beforehand. The reaction was successful and crystals were formed. (...)'. 'Using the basic ring closure mechanism we had developed starting from the observation by Jens Perregaard of the spontaneous ring closure of an ester, we were able to convert this enantiomerically pure (-)diol, via an ester, to pure (+)enantiomer of citalopram.(...)' 'This reaction is described in reaction scheme II in the escitalopram patent.'

Zelf controleren

Voor dit citaat hoeft niemand Bron op zijn woord te geloven. Het document dat rechtspraak.nl publiceerde, staat op https://bron.page/api/v1/blobs/e8978bb9a56f03d1c6a26a420e9d06118ceced8ec090bb042106f8209050b5b6. Wie het ophaalt en de SHA-256 ervan berekent, krijgt e8978bb9a56f03d1c6a26a420e9d06118ceced8ec090bb042106f8209050b5b6, en de alinea staat in dat document op bytes 71834 tot 72811.