Citaat | Rechtbank Den Haag 16 januari 2019

Onder 2.9.2. Rechtbank Den Haag 16 januari 2019

Een alinea uit Rechtbank Den Haag 16 januari 2019, ECLI:NL:RBDHA:2019:321.

LY231514 produced potent antitumor activity against the L5178Y/TK-HX- lymphoma at l00-fold lower dose levels (0.3 and 1 mg/kg/day, Figure 2) in LFD mice relative to 30 and 100 mg/kg (Table II) in mice on standard diet. It is interesting to note that the LD50 was reduced 3000-fold for lometrexol in LFD animals, and antitumor activity could not be demonstrated even at low dose levels. In contrast, the shift in both LD50 and antitumor activity for mice on LFD compared to standard diet were of a similar magnitude (approximately 100-fold) for LY231514. However, LFD animals with high levels of folate supplementation demonstrated decreased lethality to LY231514 compared to conventional diet animals, suggesting that folate intake can be manipulated to achieve greater therapeutic effects. Oral folic acid dramatically decreased the toxicity of LY231514 and preserved antitumor activity (albeit at higher dose levels) in these mice (Figure 2).

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